反应 #11381

反应方程式

potassium carbonate

2-chloro-3-nitropyridine

cyclohexylamine

→

N-Cyclohexyl-3-nitro-2-pyridineamine

溶剂

DMF

反应条件

后处理

1. 1
   萃取The solution is then extracted with 200 ml of ether
2. 2
   洗涤the organic phase is washed three times with water
3. 3
   干燥After drying over magnesium sulphate
4. 4
   其他the ether is evaporated off

实验过程

A mixture composed of 0.1 mol (15.85 g) of 2-chloro-3-nitropyridine and 0.1 mol (11.50 ml) of cyclohexylamine is heated at 120° C. for 4 hours in 250 ml of DMF in the presence of potassium carbonate (13.81 g). The solution is then extracted with 200 ml of ether and the organic phase is washed three times with water. After drying over magnesium sulphate, the ether is evaporated off.

来源