反应 #1136

反应方程式

pyridine

fumaric acid

amine

5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine

→

5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate

收率 70.0%

溶剂

methanol

反应条件

后处理

1. 1
   其他After 30 minutes the solvent was removed in vacuo

实验过程

The above described pyridine derivative was converted into invention compound of Formula I by the addition of one equivalent of fumaric acid to a methanol (15 mL) solution of the free amine at 25° C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether resulted in the formation of 5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate (70%) as a colorless solid.

来源