反应 #1135880

反应方程式

2-(chloromethyl)imidazo[1,2-a]pyridine

N-iodosuccinimide

→

2-(chloromethyl)-3-iodoimidazo[1,2-a]pyridine

收率 96.4%

溶剂

acetonitrile

反应条件

后处理

1. 1
   workup.ADDITIONwere added
2. 2
   其他The solid formed
3. 3
   其他was isolated by filtration
4. 4
   洗涤washed with 30 ml of water
5. 5
   其他dried in a vacuum bell jar

实验过程

5 g (30 mmol) of 2-(chloromethyl)imidazo[1,2-a]pyridine were solubilised in 60 ml of acetonitrile with magnetic stirring, 7.31 g (31.5 mmol) of N-iodosuccinimide were added and the mixture was stirred at r.t. for 15 min. The solid formed was isolated by filtration, washed with 30 ml of water and dried in a vacuum bell jar. 8.46 g (yield=95%) of 2-(chloromethyl)-3-iodoimidazo[1,2-a]pyridine were obtained as a white solid. LC-MS: m/z=293 (MH+); UV purity at 254 nm=99%. 1H NMR (300 MHz, DMSO) δ 8.31 (d, J=6.9 Hz, 1H), 7.58 (d, J=9.1 Hz, 1H), 7.46-7.29 (m, 1H), 7.07 (td, J=6.8, 1.0 Hz, 1H), 4.81 (s, 2H).

来源