反应 #1135873

反应方程式

2-((3-((4-fluorophenyl)ethynyl)imidazo[1,2-a]pyridin-2-yl)methoxy)acetic acid

oxalyl chloride

→

2-((3-((4-fluorophenyl)ethynyl)-imidazo[1,2-a]pyridin-2-yl)methoxy) acetyl chloride

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他the mixture was placed in a bath at 0° C.
2. 2
   其他The cold bath was withdrawn
3. 3
   浓缩The reaction medium was concentrated in vacuo

实验过程

1.5 g (4.63 mmol) of 2-((3-((4-fluorophenyl)ethynyl)imidazo[1,2-a]pyridin-2-yl)methoxy)acetic acid were suspended in 40 ml of dichloromethane with magnetic stirring, the mixture was placed in a bath at 0° C. and then 1.215 ml (13.88 mmol) of oxalyl chloride were added dropwise, finally, a few drops of dimethylformamide were added. The cold bath was withdrawn and then the mixture was stirred at r.t. for 1 h. The reaction medium was concentrated in vacuo and immediately used in the next step.

来源