反应 #1135867

ord-f504320fed6b4aacb8a6e71e66288196

反应方程式

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
apomorphine
O=C(O)CC(O)C(=O)O
Malic acid
O
Water
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.O=C([O-])CC(O)C(=O)[O-]
Apomorphine malate
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
apomorphine

反应物

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
apomorphine
O=C(O)CC(O)C(=O)O
Malic acid
O
Water

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

Apomorphine malate solution was prepared by dissolving apomorphine base in 0.1M Malic acid solution. Water was added to obtain solutions with a molar ratio of 1:1 apomorphine:malic acid, at a concentration of 2% apomorphine. The pH of each solution was 4.0. Table 5 shows the composition of each apomorphine organic salt solution.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09381249B2uspto-grants-2016_07