反应 #1135835

反应方程式

methyl 8-(4-nitrobiphenyl-3-ylamino)-8-oxooctanoate

ammonium formate

→

methyl 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate

收率 85.0%

溶剂

methanol

反应条件

后处理

1. 1
   温度The mixture was heated
2. 2
   温度to reflux under a nitrogen atmosphere overnight
3. 3
   过滤filtered
4. 4
   浓缩The filtrate was concentrated
5. 5
   其他purified by biotage column chromatography

实验过程

To a solution of methyl 8-(4-nitrobiphenyl-3-ylamino)-8-oxooctanoate (270 mg, 0.70 mmol) and ammonium formate (177 mg, 2.8 mmol) in methanol was added catalytic amount of palladium on carbon (5%). The mixture was heated to reflux under a nitrogen atmosphere overnight and filtered. The filtrate was concentrated and purified by biotage column chromatography to give methyl 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate (211 mg)

来源