反应 #1135831

反应方程式

methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(5-bromo-1H-benzimidazol-2-yl)heptanoate

收率 84.3%

溶剂

toluene

反应条件

后处理

1. 1
   浓缩concentrated
2. 2
   其他The residue was purified by biotage column chromatography

实验过程

To a solution of methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate (140 mg, 0.395 mmol) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(5-bromo-1H-benzimidazol-2-yl)heptanoate (113 mg)

来源