反应 #1135830

反应方程式

methyl 8-(4-bromo-2-nitrophenylamino)-8-oxooctanoate

SnCl2.H2O

→

methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate

收率 66.9%

溶剂

EtOH

反应条件

后处理

1. 1
   温度The reaction was heated
2. 2
   温度to reflux overnight
3. 3
   其他quenched by water
4. 4
   过滤The mixture was filtered
5. 5
   萃取the filtrate was extracted with ethyl acetate
6. 6
   其他The combined organic layer was dried
7. 7
   浓缩concentrated
8. 8
   其他purified by biotage column chromatography

实验过程

To a solution of methyl 8-(4-bromo-2-nitrophenylamino)-8-oxooctanoate (241 mg, 0.623 mmol) in EtOH was added SnCl2.H2O (490 mg, 2.37 mmol). The reaction was heated to reflux overnight and quenched by water. The mixture was filtered and the filtrate was extracted with ethyl acetate. The combined organic layer was dried, concentrated and purified by biotage column chromatography to afford methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate (149 mg)

来源