反应 #1135820

反应方程式

methyl laurate

dimethylaminobutanol

→

3-dimethylaminopropyl laurate

收率 67.0%

反应条件

后处理

1. 1
   其他A syringe was inserted
2. 2
   其他through the cap
3. 3
   其他Nitrogen was bubbled at a rate sufficient
4. 4
   workup.ADDITIONto mix the contents
5. 5
   其他set to 65° C
6. 6
   温度to cool
7. 7
   其他The Novozym 435 was removed by filtration
8. 8
   其他to afford the product as a pale, yellow oil (9.2 g; 67% yield)
9. 9
   其他without further purification

实验过程

To a 50-mL conical bottom plastic vial was added methyl laurate (38.5 mmol), dimethylaminobutanol (46.2 mmol, 1.2 eq), and Novozym 435 (400 mg). A syringe was inserted through the cap and two additional holes were punched for gas to exit. Nitrogen was bubbled at a rate sufficient to mix the contents. The vial was placed in a heating block set to 65° C. The reaction was monitored by GC/MS to observe the disappearance of starting material. The reaction was complete after approximately 24 hours. The reaction mixture was allowed to cool. The Novozym 435 was removed by filtration to afford the product as a pale, yellow oil (9.2 g; 67% yield) without further purification.

来源