反应 #1135812

反应方程式

2-methyl-3-nitrophenol

iodoethane

potassium carbonate

→

1-ethoxy-2-methyl-3-nitrobenzene

收率 100.7%

溶剂

acetone

反应条件

后处理

1. 1
   温度with heating
2. 2
   温度under reflux for ten hours
3. 3
   过滤filtered
4. 4
   浓缩the resulting filtrates were concentrated
5. 5
   萃取The resulting mixtures were extracted with ethyl acetate
6. 6
   洗涤the organic layers were washed with water and saturated saline
7. 7
   干燥were dried over anhydrous magnesium sulfate
8. 8
   浓缩were then concentrated under reduced pressure

实验过程

A mixture of 2-methyl-3-nitrophenol 33.5 g, iodoethane 41 g and potassium carbonate 90 g in acetone 400 mL was stirred with heating under reflux for ten hours. The mixtures were cooled to room temperature and filtered and the resulting filtrates were concentrated. The resulting mixtures were extracted with ethyl acetate and the organic layers were washed with water and saturated saline, and were dried over anhydrous magnesium sulfate and were then concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography to give 1-ethoxy-2-methyl-3-nitrobenzene 39.9 g.

来源