反应 #1135805

反应方程式

sodium bicarbonate

1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one

potassium carbonate

dimethyl sulfate

→

1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one

溶剂

N,N-dimethylformamide

反应条件

后处理

1. 1
   其他To the reaction mixtures
2. 2
   萃取the mixtures were extracted with ethyl acetate
3. 3
   洗涤The organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   干燥were dried over anhydrous sodium sulfate
5. 5
   浓缩The resulting mixtures were concentrated under reduced pressure

实验过程

A mixture of the above-mentioned 1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one, potassium carbonate 17.40 g, dimethyl sulfate 5.78 g and N,N-dimethylformamide 150 mL was stirred at 25° C. for one hour. To the reaction mixtures was added aqueous saturated sodium bicarbonate solution and the mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The resulting mixtures were concentrated under reduced pressure to give 1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one (hereinafter, referred to as “Intermediate (PRI-P)”) 8.10 g.

来源