反应 #1124

反应方程式

hydrochloric acid

2-chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine

sodium methoxide

water

→

2-Methoxy-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine

溶剂

dimethylformamide

methanol

反应条件

后处理

1. 1
   温度After cooling
2. 2
   萃取the reaction product is extracted with ethyl acetate
3. 3
   其他For purification it
4. 4
   其他is chromatographed

实验过程

2.21 g (6.04 mmol) of 2-chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine in 30 ml of dimethylformamide are treated with 4.31 ml of 30% strength solution of sodium methoxide in methanol and the mixture is heated at 80° C. for 1 hour. After cooling, water is added, the mixture is adjusted to pH 8 using 1/2 conc. hydrochloric acid and the reaction product is extracted with ethyl acetate. For purification it is chromatographed. Yield: 1.72 g (79%); Rf =0.4 (diisopropyl ether)

来源