反应 #1123

反应方程式

sodium hydrogencarbonate

2,4-dichloro-3-bromopyridine

cis-4-phenylcyclohexylamine

ammonium chloride

→

2-Chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)-pyridine

溶剂

N-methylpyrrolidone

反应条件

后处理

1. 1
   温度After cooling
2. 2
   萃取the reaction product is extracted with ethyl acetate
3. 3
   其他Purification

实验过程

2.27 g (10 mmol) of 2,4-dichloro-3-bromopyridine, 2.6 g (15 mmol) of cis-4-phenylcyclohexylamine and 0.1 g of ammonium chloride are heated at 120° C. for 10 hours in 10 ml of N-methylpyrrolidone. After cooling, saturated sodium hydrogencarbonate solution is added and the reaction product is extracted with ethyl acetate. Purification is carried out by column chromatography. Yield: 1.9 g (52%); m.p. 105° C.

来源