反应 #1121744

反应方程式

compound ( 1 )

Boc-Thr-Gly-OEt

sodium hydroxide

hydrochloric acid

→

Boc-Thr-Gly-OH

收率 60.2%

溶剂

methanol

反应条件

后处理

1. 1
   其他the mixture was reacted at room temperature for 3 hours
2. 2
   其他After completion of the reaction
3. 3
   萃取was extracted with a mixed solvent of ethyl acetate and n-butanol (mixing ratio=7:3)
4. 4
   浓缩The extracted objective substance was concentrated under reduced pressure
5. 5
   其他dried

实验过程

The obtained compound (1) (10.0 g, 33 mmol) was dissolved in methanol (150 mL), and 1 N aqueous sodium hydroxide (33 mL, 33 mmol) was further added thereto, and then the mixture was reacted at room temperature for 3 hours with stirring. After completion of the reaction, the reaction solution was neutralized with 1 N hydrochloric acid, and objective substance was extracted with a mixed solvent of ethyl acetate and n-butanol (mixing ratio=7:3). The extracted objective substance was concentrated under reduced pressure and dried, to obtain Boc-Thr-Gly-OH (2) (5.4 g) (yield; 60.2%).

来源