反应 #1121743

反应方程式

Boc-threonine

glycine ethyl ester hydrochloride

triethylamine

N,N′-dicyclohexylcarbodiimide

hydroxybenzotriazole

→

Boc-Thr-Gly-OEt

收率 85.4%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他the mixture was reacted at room temperature for overnight
2. 2
   其他After completion of the reaction, reaction mixture
3. 3
   过滤was filtered
4. 4
   萃取the filtrate was extracted with ethyl acetate
5. 5
   浓缩The extract was concentrated under reduced pressure
6. 6
   其他the product was crystallized from hexane

实验过程

Boc-threonine (produced by Wako Pure Chemical Industries Ltd.) (11.0 g, 50 mmol) and glycine ethyl ester hydrochloride (produced by Wako Pure Chemical Industries Ltd.) (8.4 g, 60 mmol) were dissolved in dichloromethane (250 mL). After triethylamine (8.4 mL, 60 mmol), N,N′-dicyclohexylcarbodiimide (DCC, 12.4 g, 60 mmol) and hydroxybenzotriazole (9.2 g, 60 mmol) were further added thereto, the mixture was reacted at room temperature for overnight with stirring. After completion of the reaction, reaction mixture was filtered, and then the filtrate was extracted with ethyl acetate. The extract was concentrated under reduced pressure, and the product was crystallized from hexane, to obtain Boc-Thr-Gly-OEt (1) (13.0 g) (yield; 85.1%).

来源