反应 #1121716

反应方程式

hydroquinone

1,6-dibromo hexane

Potassium hydroxide

→

4-(6-bromohexyloxy)phenol

收率 39.4%

溶剂

methanol

反应条件

后处理

1. 1
   其他fluxed at 60° C.
2. 2
   其他(Celsius) overnight
3. 3
   其他is lowered to a room temperature
4. 4
   其他methanol was evaporated from the reaction mixture
5. 5
   萃取Then, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters))
6. 6
   其他Water was removed over magnesium sulfate
7. 7
   其他the solvents were evaporated
8. 8
   其他the resulting reaction mixture
9. 9
   其他was purified

实验过程

As shown in the following Scheme, hydroquinone (1) (4.5 g (grams)) and 1,6-dibromo hexane (2) (10 g (grams)) were dissolved in methanol (100 ml (milliliters)) at a room temperature. Potassium hydroxide (2.3 g (grams)) was added to the resulting mixture solution, and then fluxed at 60° C. (Celsius) overnight. Next day, the temperature of the reaction mixture is lowered to a room temperature, and methanol was evaporated from the reaction mixture. Then, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters)). Water was removed over magnesium sulfate, and the solvents were evaporated, and the resulting reaction mixture was purified using a column chromatography (developer solution: ethylacetate/hexane=1/5 volume ratio) to obtain 4.4 g (grams) of 4-(6-bromohexyloxy)phenol (3).

来源