反应 #1106664

反应方程式

1,2,3,4-tetrafluoro-5,8-dihydroxyanthraquinone

N,N-dimethylethylenediamine

→

Compound 1

1,4-bis(2-(dimethylamino)ethylamino)-2,3-difluoro-5,8-dihydroxyanthracene-9,10-dione

溶剂

CH2Cl2

反应条件

后处理

1. 1
   其他After evaporation of the solvents
2. 2
   其他the residue was purified by silica gel chromatography

实验过程

A mixture of 1,2,3,4-tetrafluoro-5,8-dihydroxyanthraquinone (1.0 g, 3.2 mmol) and N,N-dimethylethylenediamine (3 mL) in CH2Cl2 (30 mL) was stirred at room temperature for 12 hours. After evaporation of the solvents, the residue was purified by silica gel chromatography using isocratic solvent system of EtOAc/MeOH/Et3N (10:10:1) yielding 830 mgs of Compound 1 as dark blue product. Abs (max, PBS pH 7.4)=568 nm; Em=675 nm. The structure of Compound 1 is given below:

来源