反应 #11044

反应方程式

Methyl (2S)-3-(3′-amino[1,1′-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate

3,4-diethoxy-3-cyclobuten-1,2-dion

→

title compound

收率 59.0%

Methyl (2S)-3-{3′-[(2-ethoxy-3,4-dioxo-1-cyclobuten-1-yl)-amino][1,1′-biphenyl]-4-yl}-2-mesitylsulfonylamino-propanoate

收率 59.0%

溶剂

1 propanol

反应条件

后处理

1. 1
   温度refluxed for 20 h
2. 2
   其他Purification by flash chromatography (dichloromethane/acetic acid ethyl ester 10+1)

实验过程

2 g of Methyl (2S)-3-(3′-amino[1,1′-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate 12.1.2 were mixed with 0.75 g 3,4-diethoxy-3-cyclobuten-1,2-dion in 40 ml 1 propanol and refluxed for 20 h. Purification by flash chromatography (dichloromethane/acetic acid ethyl ester 10+1) yielded 1,5 g of the title compound.

来源