反应 #1095847

反应方程式

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

溶剂

piperidine

dimethylformamide

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated under vacuum, water
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   萃取the product was extracted with ethyl acetate
4. 4
   其他The crude product was purified by conversion into its hydrochloride salt

实验过程

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) was dissolved in 20% piperidine in dimethylformamide at 0° C. The solution was continued stifling for 1 h. The reaction mixture was concentrated under vacuum, water was added to the residue, and the product was extracted with ethyl acetate. The crude product was purified by conversion into its hydrochloride salt.

来源