反应 #1095846

反应方程式

ethyl acrylate

ethyl glycinate hydrochloride

sodium hydroxide

→

Diethyl-2-azabutane-1,4-dicarboxylate

溶剂

water

反应条件

后处理

1. 1
   其他After 19 h the solution was partitioned with dichloromethane (3×100 mL)
2. 2
   干燥The organic layer was dried with anhydrous sodium sulfate
3. 3
   过滤filtered
4. 4
   其他evaporated
5. 5
   workup.DISTILLATIONThe residue was distilled
6. 6
   其他to afford AA (28.8 g, 61%)

实验过程

A 4.7 M aqueous solution of sodium hydroxide (50 mL) was added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) was added and the mixture was stirred at room temperature until completion of the reaction was ascertained by TLC. After 19 h the solution was partitioned with dichloromethane (3×100 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and evaporated. The residue was distilled to afford AA (28.8 g, 61%).

来源