反应 #1076765

反应方程式

xylene

3-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)propanol

hydrobromic acid

→

1-bromo-3-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)propane

收率 37.0%

溶剂

water

反应条件

后处理

1. 1
   其他obtained by the procedures
2. 2
   其他was removed by azeotropic distillation
3. 3
   workup.ADDITIONTo the reaction mixture was added 1.0 l of toluene, and it
4. 4
   洗涤was washed with 300 ml of saturated aqueous sodium carbonate solution twice
5. 5
   干燥with 400 ml of water thrice, and then dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off under a reduced pressure

实验过程

To 350 ml of xylene were added 341 g (1280 mmol) of the crude 3-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)propanol obtained by the procedures described above and 881 g (5120 mmol) of 47% hydrobromic acid, water was removed by azeotropic distillation, and then the mixture was stirred at 150° C. for 2 hours. To the reaction mixture was added 1.0 l of toluene, and it was washed with 300 ml of saturated aqueous sodium carbonate solution twice and with 400 ml of water thrice, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under a reduced pressure, and the residue was subjected to silica gel column chromatography (eluent: heptane) to obtain 156 g of a crude 1-bromo-3-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)propane.

来源