反应 #1076762

反应方程式

1-methoxy-4-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)butene

formic acid

→

4-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)butanal

收率 94.7%

溶剂

toluene

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   温度they were heated
3. 3
   温度to reflux for 4 hours
4. 4
   洗涤The reaction mixture was washed with 300 ml of saturated aqueous sodium bicarbonate solution twice
5. 5
   workup.DISTILLATIONwith 500 ml of water five times, and the solvent was distilled off under a reduced pressure

实验过程

In 500 ml of toluene was dissolved 50.0 g (171 ml ) of the crude 1-methoxy-4-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)butene obtained by the procedures in the fourth step, 78.7 g (1710 mmol) of formic acid was added thereto, and then they were heated to reflux for 4 hours. The reaction mixture was washed with 300 ml of saturated aqueous sodium bicarbonate solution twice and with 500 ml of water five times, and the solvent was distilled off under a reduced pressure to obtain 45.1 g of a crude 4-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)butanal.

来源