反应 #1076760

反应方程式

2-(2-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)ethyl)-1,3-dioxane

formic acid

→

3-(trans-4-(trans-4-propylcyclohexyl)-cyclohexyl)propanal

收率 97.6%

溶剂

toluene

反应条件

后处理

1. 1
   其他obtained by the procedures
2. 2
   workup.ADDITIONwas added
3. 3
   温度they were heated
4. 4
   温度to reflux for 4 hours
5. 5
   洗涤The reaction mixture was washed with 600 ml of saturated aqueous sodium bicarbonate solution twice
6. 6
   workup.DISTILLATIONwith 1.0 l of water five times, and the solvent was distilled off under a reduced pressure

实验过程

In 3.0 l of toluene was dissolved 300 g (930 mmol) of the 2-(2-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)ethyl)-1,3-dioxane obtained by the procedures described above, 428 g (9300 mmol) of formic acid was added thereto, and they were heated to reflux for 4 hours. The reaction mixture was washed with 600 ml of saturated aqueous sodium bicarbonate solution twice and with 1.0 l of water five times, and the solvent was distilled off under a reduced pressure to obtain 240 g of a crude 3-(trans-4-(trans-4-propylcyclohexyl)-cyclohexyl)propanal.

来源