反应 #10662

反应方程式

Intermediate 121

trans-N-(tert-butoxycarbonyl)-4-[(4-bromo-5-isoquinolyl)oxy]cyclohexylamine

DMF

→

title compound

trans-N-(tert-butoxycarbonyl)-4-[(4-cyano-5-isoquinolyl)oxy]cyclohexylamine

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated under reduced pressure
2. 2
   其他the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1)

实验过程

A suspension of Intermediate 121 (113.7 mg), zinc cyanide (19.4 mg, Wako Pure Chemical Industries), tris(dibenzylideneacetone)dipalladium(0) (24.0 mg) and 1,1′-bis(diphenylphosphino)ferrocene (35.3 mg, Tokyo Kasei Kogyo) in DMF (2 ml) was stirred at 120° C. for 19 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (34.9 mg).

来源