反应 #1050686

反应方程式

ethyl acetate

p-toluene-sulfonic acid

2-formyl-5-methylthiophene

methyl orthoformate

→

2-dimethoxymethyl-5-methylthiophene

收率 78.5%

溶剂

toluene

反应条件

后处理

1. 1
   其他To the cooled reaction mixture
2. 2
   洗涤washed with water twice
3. 3
   干燥The organic layer was dried over magnesium sulfate
4. 4
   其他Removal of the solvent
5. 5
   其他gave a brownish oil, which
6. 6
   workup.DISTILLATIONwas purified by distillation under reduced pressure

实验过程

A mixture of 2-formyl-5-methylthiophene (12.6 g, 0.1 mol), methyl orthoformate (31.8 g) and a catalytic amount of p-toluene-sulfonic acid in toluene (120 ml) was refluxed for 6 hours. To the cooled reaction mixture was added ethyl acetate and washed with water twice. The organic layer was dried over magnesium sulfate. Removal of the solvent gave a brownish oil, which was purified by distillation under reduced pressure to afford 2-dimethoxymethyl-5-methylthiophene (13.54 g, 78.5% yield) as a yellow oil.

来源