反应 #1045

反应方程式

2,3,3-trifluoro-2-propenyl bromide

triethyl phosphite

→

diethyl (1,1,2-trifluro-2-propenyl)phosphonate

收率 11.0%

diethyl (2,3,3-trifluro-2-propenyl)phosphonate

收率 14.0%

反应条件

后处理

1. 1
   温度at reflux for overnight
2. 2
   其他The residue obtained
3. 3
   其他after evaporation of the solvent
4. 4
   其他was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1)

实验过程

A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonltrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluro-2-propenyl)phosphonate (1.0 g, 14%).

来源