反应 #1044

反应方程式

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

收率 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

收率 94.2%

溶剂

ethyl acetate

反应条件

后处理

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   过滤filtered
3. 3
   其他The residue obtained
4. 4
   其他after evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   过滤filtered
7. 7
   其他Evaporation of the solvent

实验过程

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

来源