反应 #10409

反应方程式

2-Amino-4,5-difluorobenzoic acid, 2,2-dibenzylhydrazide

triphosgene

NaHCO3

→

title compound

收率 198.7%

3-Dibenzylamino-6,7-difluoro-1H-quinazoline-2,4-dione

收率 198.7%

溶剂

methylene chloride

反应条件

后处理

1. 1
   其他the layers are separated
2. 2
   洗涤the aqueous layer is washed three times with ethyl acetate
3. 3
   干燥The combined organic layers are dried over magnesium sulfate
4. 4
   浓缩concentrated

实验过程

2-Amino-4,5-difluorobenzoic acid, 2,2-dibenzylhydrazide (Example 15) (0.81 g, 2.2 mmol) and triphosgene (0.33 g, 1.1 mmol) are combined in 100 mL of methylene chloride and stirred at 25° C. for 20 hours. The solution is poured into 200 mL of saturated NaHCO3, the layers are separated, and the aqueous layer is washed three times with ethyl acetate. The combined organic layers are dried over magnesium sulfate and then concentrated to give 0.86 g of the title compound as a solid. MS CI: m/z 394 (MH+).

来源