反应 #1029

反应方程式

2-acetyl-4-(pyrid-2-yl)-pyrimidine

hydroxylamine

sodium acetate

→

2-acetyl-4-(pyrid-2-yl)-pyrimidine oxime

收率 91.1%

溶剂

water

ethanol

water

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度to reflux for 1.5 hours
3. 3
   过滤filtered
4. 4
   洗涤washed with hexane

实验过程

A solution of 2-acetyl-4-(pyrid-2-yl)-pyrimidine (1.0 g), hydroxylamine (0.39 g) and sodium acetate (0.62 g) in a mixture of ethanol (10 ml) and water (2 ml) was heated to reflux for 1.5 hours. The reaction was then poured into water the precipitate filtered and washed with hexane to give 2-acetyl-4-(pyrid-2-yl)-pyrimidine oxime (0.98 g, 91% yield) as a white crystalline solid m.p. 196°-8° C.; 1H NMR: 2.50(3H,s); 7.42(1H,m); 7.88(1H,m); 8.30(1H,d); 8.59(1H,d); 8.74(1H,d); 8.90(1H,d); 10.85(1H,brs) ppm.

来源