反应 #1028

反应方程式

3-acetyl-isoquinoline

hydroxylamine

sodium acetate

→

3-acetyl-isoquinoline oxime

收率 89.0%

溶剂

water

methanol

water

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度to reflux for 1.5 hours
3. 3
   萃取extracted with ethyl acetate
4. 4
   其他The combined extracts were dried
5. 5
   浓缩concentrated
6. 6
   其他triturated with hexane

实验过程

A solution of 3-acetyl-isoquinoline (0.65 g), hydroxylamine (0.29 g) and sodium acetate (0.47 g) in a mixture of methanol (20 ml) and water (3 ml) was heated to reflux for 1.5 hours. The reaction was then poured into water and extracted with ethyl acetate. The combined extracts were dried, concentrated and triturated with hexane to give 3-acetyl-isoquinoline oxime (0.63, 89% yield) as a white crystalline solid m.p. 135°-142° C.; 1H NMR: 2.50(3H,s); 7.61(1H,t); 7.70(1H,t); 7.87(1H,d); 7.99(1H,d); 8.11(1H,s); 9.28(1H,s) ppm.

来源