反应 #10267

反应方程式

NaOH

acetaldehyde

O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride

NaOH

→

2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime

收率 100.0%

溶剂

water

water

反应条件

后处理

1. 1
   萃取extracted with dichloromethane
2. 2
   干燥The organic layer was dried (Na2SO4)
3. 3
   浓缩concentrated in vacuo

实验过程

A mixture of acetaldehyde (0.1 mL of a 50 wt % soln. in water), O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride (0.14 g), NaOH (2N, 0.64 mL) and water (5 mL) was stirred at room temperature overnight. The solution was made basic with NaOH (1N) and extracted with dichloromethane. The organic layer was dried (Na2SO4), and concentrated in vacuo to afford 2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime (0.13 g, ˜100%), which was used as such.

来源