反应 #10254

反应方程式

FMOC-N-isobutylglycine

thionyl chloride

DMF

→

FMOC-Leu

溶剂

Cl2

反应条件

后处理

1. 1
   其他FMOC-Leu*-Cl was prepared
2. 2
   浓缩concentrated in vacuo
3. 3
   workup.DISSOLUTIONrepeatedly dissolving in CH2 Cl2 (3××)

实验过程

FMOC-Leu*-Cl was prepared by dissolving FMOC-N-isobutylglycine (150 mg, 0.42 mmol) in CH2 Cl2 (2.8 mL), and adding thionyl chloride (309 μL, 4.2 mmol) and 3 μL DMF (0.04 mmol). The reaction mixture was stirred for 5 hours and concentrated in vacuo, repeatedly dissolving in CH2 Cl2 (3××) to provide FMOC-Leu*-Cl as a colorless oil (146 mg, 92%): IR (cm−1) -1804, 1720, 1715. FMOC-Phe*-Cl was similarly prepared.

来源