反应 #1010611

反应方程式

(R)-tert-butyl 2-amino-2-phenylacetate hydrochloride

ethyl 4-bromobutanoate

K2CO3

→

title compound

收率 74.0%

(R)-ethyl 4-(2-tert-butoxy-2-oxo-1-phenylethylamino)butanoate

收率 74.0%

溶剂

CH3CN

EtOAc

反应条件

后处理

1. 1
   洗涤washed with H2O and brine
2. 2
   干燥The organic was then dried (MgSO4)
3. 3
   过滤filtered
4. 4
   浓缩concentrated
5. 5
   其他Purification by chromatography (silica gel, 40% EtOAc in Hexanes)

实验过程

A mixture of (R)-tert-butyl 2-amino-2-phenylacetate hydrochloride (0.5 g, 2.051 mmol), ethyl 4-bromobutanoate (0.44 g, 2.26 mmol), and K2CO3 (1.13 g, 8.21 mmol) in CH3CN (10 mL) was heated to 50° C. for 40 hours. The mixture was diluted with EtOAc and then washed with H2O and brine. The organic was then dried (MgSO4), filtered and concentrated. Purification by chromatography (silica gel, 40% EtOAc in Hexanes) afforded 486 mg (74%) of the title compound. MS (ESI) m/z 322 (M+H)+.

来源