反应 #1010606

反应方程式

(R)-tert-butyl 2-amino-2-phenylacetate hydrochloride

acetaldehyde

→

title compound

收率 110.6%

(R)-tert-butyl 2-(ethylamino)-2-phenylacetate

收率 110.6%

溶剂

MeOH

反应条件

后处理

1. 1
   其他the ice bath was removed
2. 2
   workup.STIRRINGstirred at rt for 45 mins
3. 3
   过滤The mixture was filtered through celite
4. 4
   洗涤washed with methanol
5. 5
   浓缩the filtrate was concentrated in vacuo

实验过程

To a solution of (R)-tert-butyl 2-amino-2-phenylacetate hydrochloride (0.25 g, 1.026 mmol) in MeOH (10.26 mL) was added 10% Pd/C (0.080 g, 1.026 mmol). The resulting mixture was cooled to 0° C., and acetaldehyde (0.576 mL, 10.26 mmol) was added. The resulting mixture was stirred at 0° C. for 10-15 mins, the ice bath was removed, and the mixture was placed under a hydrogen balloon and stirred at rt for 45 mins. The mixture was filtered through celite, washed with methanol, and the filtrate was concentrated in vacuo to give the title compound (0.267 g).

来源