反应 #1010593

反应方程式

(R)-tert-butyl 2-amino-2-phenylacetate HCL

cyanoborohydride

acetic acid

glutaraldehyde

→

title compound

(R)-tert-butyl 2-phenyl-2-(piperidin-1-yl)acetate

溶剂

MeOH

CH2Cl2

water

反应条件

后处理

1. 1
   过滤the reaction filtered
2. 2
   洗涤washed with MeOH
3. 3
   浓缩concentrated
4. 4
   洗涤washed with saturated NaHCO3
5. 5
   干燥dried (Na2SO4)
6. 6
   浓缩concentrated

实验过程

To a slurry of (R)-tert-butyl 2-amino-2-phenylacetate HCL (Chem-Impex, 0.200 g, 0.821 mmol), MP-cyanoborohydride (2.44 mmol/g; 500 mg) and acetic acid (0.141 mL, 2.462 mmol) in MeOH (2.00 mL) and CH2Cl2 (2 mL) at rt was added glutaraldehyde (0.155 mL, 0.821 mmol) as a 50% solution in water. The reaction was stirred for 30 min., the reaction filtered, washed with MeOH and concentrated. The residue was taken up in CH2Cl2, washed with saturated NaHCO3, dried (Na2SO4) and concentrated to give the title compound. MS (DCI; M+H) m/z=276.

来源