反应 #1005985

反应方程式

2-chloromethylquinoline hydrochloride

potassium carbonate

tert-butyl piperazine-1-carboxylate

→

2-(piperazin-1-ylmethyl)quinoline

收率 92.0%

溶剂

acetone

反应条件

后处理

1. 1
   其他Reaction
2. 2
   过滤filtered through celite
3. 3
   浓缩Filtrate was concentrated on Rotavapor under vacuum
4. 4
   其他the crude residue was purified on SiO2 using Biotage SP1

实验过程

To a solution of 2-chloromethylquinoline hydrochloride (5 mmol) in anhydrous acetone (100 mL) was added, anhydrous potassium carbonate (15 mmol) and tert-butyl piperazine-1-carboxylate (7 mmol) and the reaction mixture was stirred under reflux conditions for 12 h. Reaction was cooled to r.t. and filtered through celite. Filtrate was concentrated on Rotavapor under vacuum and the crude residue was purified on SiO2 using Biotage SP1 to give a pure 2-(piperazin-1-ylmethyl)quinoline (6.3, 92%, pale yellow solid).

来源