反应 #1005973

反应方程式

levothyroxine sodium

mannitol

propyl gallate

sucrose

→

Levothyroxine

溶剂

water

—

alcohol

反应条件

后处理

1. 1
   其他milled
2. 2
   workup.ADDITIONwere added over about 10 minutes
3. 3
   其他The wet granulation was dried at a temperature below 60° C. until the moisture content

实验过程

The microcrystalline cellulose, mannitol, and sucrose were screened or milled and then blended with levothyroxine sodium for about 6 minutes. Acacia, dissolved in water, and propyl gallate, dissolved in alcohol, were added over about 10 minutes to granulate the mixture. The wet granulation was dried at a temperature below 60° C. until the moisture content was less than about 4%. The dried granulation was sized by passing it through a mill, and then blended with the additional ingredients listed in the table below using conventional mixing equipment.

来源