反应 #1005957

反应方程式

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

收率 95.2%

溶剂

methanol

water

反应条件

后处理

1. 1
   萃取extracted twice with ethyl acetate
2. 2
   洗涤washed with water
3. 3
   干燥dried over anhydrous magnesium sulfate
4. 4
   过滤The desiccant was filtered
5. 5
   其他separated
6. 6
   其他the solvent was evaporated off under reduced pressure

实验过程

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

来源