反应 #1005943

反应方程式

water

methyl N-methoxycarbamate

1-(4-chloro-phenyl)-3-[[(2R,3S)-3-methyloxiran-2-yl]methoxy]pyrazole

→

5-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methoxy-4-methyl-oxazolidin-2-one

溶剂

DMSO

反应条件

后处理

1. 1
   workup.ADDITIONhave been added
2. 2
   workup.STIRRINGThe mixture was stirred at 90° C. for 20 h
3. 3
   萃取extracted thrice with 30 ml ethyl acetate each, the combined extracts
4. 4
   干燥have been dried with sodium sulfate
5. 5
   其他the solvent removed in vacuo
6. 6
   其他The crude product (2.5 g) was used without further purification

实验过程

To 1.08 g (10.0 mmol) methyl N-methoxycarbamate in 17 ml DMSO have been added with stirring at ambient temperature 1.00 g (8.9 mmol) potassium tert.-butylate. Stirring has been continued for 5 min before 2.00 g (7.56 mmol) 1-(4-chloro-phenyl)-3-[[(2R,3S)-3-methyloxiran-2-yl]methoxy]pyrazole have been added. The mixture was stirred at 90° C. for 20 h. After cooling to ambient temperature the reaction mixture was poured into 150 ml of water, extracted thrice with 30 ml ethyl acetate each, the combined extracts have been dried with sodium sulfate and the solvent removed in vacuo. The crude product (2.5 g) was used without further purification.

来源