反应 #10036

反应方程式

(2S,4R)-trans-4-hydroxyproline

formamide

hydrogen

→

title compound

收率 92.1%

(2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid

收率 92.1%

溶剂

ethanol

water

反应条件

后处理

1. 1
   其他After removing the palladium on charcoal
2. 2
   过滤by filtration
3. 3
   其他the water of the filtrate was removed by distillation under reduced pressure
4. 4
   其他The solid residue thus obtained
5. 5
   其他The crystals which precipitated
6. 6
   过滤were collected by filtration

实验过程

A suspension of (2S,4R)-trans-4-hydroxyproline (5 g), 37% aqueous formamide solution (4.6 g) and 7.5% palladium on charcoal (53% water content, 3.2 g) in water (15 mL) was stirred at room temperature in an atmosphere of high-pressure hydrogen for 10 hours. After removing the palladium on charcoal by filtration, the water of the filtrate was removed by distillation under reduced pressure. The solid residue thus obtained was suspended and stirred in ethanol (25 mL). The crystals which precipitated were collected by filtration to give the title compound (5.1 g, yield 92%).

来源