子结构搜索

483845

C#CCN1C(=O)C(CC#N)C(CC)(CC)N=C1c1ccccc1

6-ethyl-5-cyanomethyl-6-ethyl-2-phenyl-3-propargyl-4(3H)-pyrimidinone

收率 49.8%DOI: 10.6084/m9.figshare.5104873.v1

Nc1ccc(-c2csc3c(C#CCN4C(=O)c5ccccc5C4=O)cnc(N)c23)cc1

Reaction #45448

desired product

收率 43.4%DOI: 10.6084/m9.figshare.5104873.v1

CNCCCN1c2ccccc2CCc2ccccc21

Reaction #57129

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN(CC)CC)nc2cc1Cl)c1ccc(C(=O)OC(C)(C)C)cc1

Reaction #76131

tert-Butyl 4-[N-[2-Diethylaminomethyl-7-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCOCC3)nc2cc1Cl)c1ccc(C(=O)OC(C)(C)C)cc1

Reaction #76132

tert-Butyl 4-[N-[7-Chloro-3-methyl-2-morpholinomethyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCC(O)CC3)nc2cc1Cl)c1ccc(C(=O)OC(C)(C)C)cc1

Reaction #76133

tert-Butyl 4-[N-[7-Chloro-3-methyl-2-(4-hydroxypiperidin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)[nH]c(CO)nc2cc1Cl)c1ccc(C(=O)OC(C)(C)C)cc1

Reaction #76135

收率 70.0%DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(CCN(C)C)c(CN3CCCCC3)nc2cc1Cl)c1ccc(C(=O)OC(C)(C)C)cc1

Reaction #76136

收率 26.0%DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN(CC)CC)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76141

4-[N-[2-Diethylaminomethyl-7-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCCCC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76142

4-[N-[7-Chloro-3-methyl-4-oxo-2-piperidinomethyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCOCC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76143

4-[N-[7-Chloro-3-methyl-2-morpholinomethyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCN(CCO)CC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76144

4-[N-[7-Chloro-3-methyl-2-(4-(2-hydroxyethyl)-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCN(c4ccccc4)CC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76145

4-[N-[7-Chloro-3-methyl-4-oxo-2-(4-phenylpiperazin-1-yl)methyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCC(O)CC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76146

4-[N-[7-Chloro3-methyl-2-(4-hydroxypiperidin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(C)c(CN3CCN(C)CC3)nc2cc1Cl)c1ccc(C(=O)NCCCn2ccnc2)cc1

Reaction #76147

4-[N-[7-Chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-[3-(1H-imidazol-1-yl)propyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(CC(=O)N(CC)CC)c(CN3CCCCC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76148

4-[N-[7-Chloro-3-diethylcarbamoylmethyl-4-oxo-2-(piperidin-1-yl)methyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(CC(=O)OC)c(CN3CCCCC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76149

4-[N-[7-Chloro-3-methoxycarbonylmethyl-4-oxo-2-piperidin-1-ylmethyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(Cc1cc2c(=O)n(CCN(C)C)c(CN3CCCCC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1

Reaction #76150

收率 24.4%DOI: 10.6084/m9.figshare.5104873.v1

O=C1c2ccccc2C(=O)N1CCCc1ccc(CCCN2C(=O)c3ccccc3C2=O)nc1

Reaction #77852

收率 63.8%DOI: 10.6084/m9.figshare.5104873.v1

C#CCN(CCC(=O)OCC)C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C.Cl

Reaction #78620

1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-propargyl-N-(2-ethoxycarbonylethyl)amide hydrochloride

收率 81.0%DOI: 10.6084/m9.figshare.5104873.v1

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