Реакция #999989

Уравнение реакции

4-(3,5,6-Trifluoro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

4-(3,5,6-Trifluoro-pyridin-2-yl)-piperazine-1-carboxylic Acid tert-butyl Ester

Red-Al

→

title compound

4-(3,5-Difluoro-pyridin-2-yl)-piperazine-1-carboxylic Acid tert-butyl Ester

Растворители

toluene

Условия реакции

Обработка

1. 1
   Другоеquenched by the addition of water (50 mL)
2. 2
   ЭкстракцияThe mixture was extracted with EtOAc (2×40 mL)
3. 3
   Промывкаthe combined organic phases were washed with brine (50 mL)
4. 4
   Сушкаdried over Na2SO4
5. 5
   Фильтрацияfiltered
6. 6
   КонцентрированиеThe filtrate was concentrated in vacuo
7. 7
   Другоеthe residue was purified by silica gel chromatography
8. 8
   Промывкаeluting with 20% EtOAc/hexane

Методика

(Analogous to the procedure of Hee-Gweon Woo; Bo-Hye, Kim and Sun-Jung Song, Bull. Korean Chem. Soc. 1999, 20, 865-866). 4-(3,5,6-Trifluoro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester from step (a) above (950 mg, 3 mmol) was added to a mixture of bis(cyclopentadienyl)titanium dichloride (37 mg, 0.15 mmol, Aldrich) and Red-Al (1.32 mL, Aldrich) in toluene (3 mL). The reaction mixture was stirred at room temperature for 3 h and quenched by the addition of water (50 mL). The mixture was extracted with EtOAc (2×40 mL) and the combined organic phases were washed with brine (50 mL), dried over Na2SO4, and filtered. The filtrate was concentrated in vacuo and the residue was purified by silica gel chromatography, eluting with 20% EtOAc/hexane to give the title compound as a light-yellow oil. MS (ESI, pos. ion) m/z: 300 (M+1).

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