Реакция #9985

Уравнение реакции

(S)-1,2,3,5,6,7,8,8a-octahydroindolizin-5,7-dione

pyrrolidine

→

pyrrolidine

title compound

(S)-7-(1-Pyrrolidinyl)-1,2,3,5,8,8a-hexahydroindolizin-5-one

Растворители

ethanol

Условия реакции

Обработка

1. 1
   КонцентрированиеAt the end of this time, the reaction mixture was concentrated by distillation under reduced pressure
2. 2
   Другоеto remove solvents

Методика

(S)-1,2,3,5,6,7,8,8a-octahydroindolizin-5,7-dione (117 mg (0.76 mmol), prepared as described in 3)) was dissolved in ethanol (1.2 ml). To the solution was added pyrrolidine (128 μl, 1.53 mmol), and the resulting mixture was allowed to stand at room temperature for 5 minutes. At the end of this time, the reaction mixture was concentrated by distillation under reduced pressure to remove solvents and any excess of pyrrolidine, to give the title compound (160 mg) as a light yellow powder (yield quantitative).

Источник