Реакция #9984

Уравнение реакции

(8aS)-6-Methoxycarbonyl-1,2,3,5,6,7,8,8a-octahydroindolizin-5,7-dione

sodium hydrogencarbonate

→

title compound

Выход 87.8%

(S)-1,2,3,5,6,7,8,8a-Octahydroindolizin-5,7-dione

Выход 87.8%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Температураcooled to room temperature
2. 2
   ЭкстракцияThe mixture was extracted with a solution of dichloromethane and isopropanol (4:1)
3. 3
   ПромывкаThe organic layer was washed with water
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   Другоеthe solvent was removed by distillation under reduced pressure

Методика

(8aS)-6-Methoxycarbonyl-1,2,3,5,6,7,8,8a-octahydroindolizin-5,7-dione (183 mg (0.87 mmol), prepared as described in 2)) was dissolved in an aqueous solution of 10% acetic acid (2 ml). The resulting mixture was stirred at 110° C. for 30 minutes, and then cooled to room temperature. To the reaction mixture was added a saturated aqueous solution of sodium hydrogencarbonate and the mixture was made alkaline. The mixture was extracted with a solution of dichloromethane and isopropanol (4:1). The organic layer was washed with water, dried over anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure, to give the title compound (117 mg) as a pale brown oil (yield 87%).

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