Реакция #9962

Уравнение реакции

6-Amino-5-chloro-2-methylbenzoxazole

sulfuryl chloride

→

6-Amino-5,7-Dichloro-2-Methylbenzoxazole

Растворители

ethyl acetate

ethyl acetate

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   ФильтрацияAfter 1 hour the precipitate was filtered off
3. 3
   Промывкаwashed with ether
4. 4
   Другоеair-dried

Методика

6-Amino-5-chloro-2-methylbenzoxazole (10 g, 54.76 mMole) was dissolved in ethyl acetate (150 mL). At room temperature and with good stirring, sulfuryl chloride (8.8 mL, 109.52 mMole) was added drop by drop over a 20-minute period. As the addition proceeds, additional ethyl acetate (350 mL) was added to keep the mixture stirring. After 1 hour the precipitate was filtered off, washed with ether and air-dried. Yield 10.5 g.

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