Реакция #993

Уравнение реакции

Chloroacetylchloride

2-aminopyridine

diisopropylethylamine

→

brown solid

Выход 80.1%

2-Chloro-N-(2-pyridinyl)acetamide

Выход 80.1%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеthe temperature below 5° C
2. 2
   Фильтрацияwas filtered
3. 3
   Промывкаwashed with water
4. 4
   СушкаThe organic layer was dried (MgSO4)
5. 5
   Другоеevaporated under reduced pressure

Методика

Chloroacetylchloride (60 g, 0.53M) was added with stirring to a mixture of 2-aminopyridine (50 g, 0.53M) and diisopropylethylamine (75 ml, 0.53M) in dichloromethane (500 ml) keeping the temperature below 5° C. After the reaction mixture was warmed to room temperature it was filtered and washed with water. The organic layer was dried (MgSO4) and evaporated under reduced pressure to give 72.6 g of a brown solid.

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