Реакция #992706

Уравнение реакции

5-aminouracil

4,4′-difluorobenzophenone

→

N-(5-uracil-yl)-4,4′-difluorobenzophenone imine

Растворители

—

hexanes

N-methylpyrrolidone N-cyclohexylpyrrolidone

Условия реакции

Обработка

1. 1
   ДругоеIn a round bottom flask equipped with an overhead stirrer
2. 2
   workup.ADDITIONwas added to fully induce precipitation
3. 3
   Другоеthe solid was isolated by filtration
4. 4
   Другоеtwice recrystallized from isopropanol
5. 5
   ПромывкаThe product was rinsed with isopropanol, suction
6. 6
   Другоеdried
7. 7
   Другоеvacuum dried in an oven overnight

Методика

In a round bottom flask equipped with an overhead stirrer, 1.16 grams (0.009 mole) of 5-aminouracil was charged along with 6 grams (0.027 mole) of 4,4′-difluorobenzophenone and a N-methylpyrrolidone/N-cyclohexylpyrrolidone solvent mixture (50/50, 20 milliliters). The reaction mixture was then heated to 180° C. for 3 days. A charge of hexanes (100 milliliters) was added to fully induce precipitation, and the solid was isolated by filtration and twice recrystallized from isopropanol. The product was rinsed with isopropanol, suction dried, and vacuum dried in an oven overnight.

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