Реакция #988297

Уравнение реакции

MeOH

Urocanic acid

compound i

Urocanic acid

→

3-(1H-Imidazol-5-yl)-propionic acid

Растворители

HCl

Условия реакции

Обработка

1. 1
   ДругоеThe catalyst was removed by filtration through a 3 cm pad of diatomaceous earth
2. 2
   Концентрированиеthe filtrate was concentrated to a solid
3. 3
   Другоеdried overnight under vacuum
4. 4
   ДругоеThe crude material was used without further purification

Методика

Urocanic acid (compound i, where R2 is H)(1.38 g, 10.0 mmol) was dissolved in 5% aqueous HCl (20 ml) plus MeOH (15 ml) containing 10% Pd on carbon (100 mg) and the mixture was shaken overnight under about 30 psi H2. The catalyst was removed by filtration through a 3 cm pad of diatomaceous earth and the filtrate was concentrated to a solid and dried overnight under vacuum. The crude material was used without further purification. Mass spec. 141.4 MH+

Источник