Реакция #9863

Уравнение реакции

2-Amino-thiophene-3-carboxlic acid amide

potassium ethylxanthate

→

title compound

Выход 69.5%

2-Thioxo-2,3-dihydro-1H-thieno[2,3-d]pyrimidin-4-one

Выход 69.5%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe solvent (DMF) was removed on the rotovap under high vacuum at 90° C
2. 2
   workup.ADDITIONThe residue was diluted with 600 mL of aqueous citric acid (5%)
3. 3
   Температураcooled to 0° C.
4. 4
   ФильтрацияThe tan powder was filtered
5. 5
   Другоеdried overnight

Методика

2-Amino-thiophene-3-carboxlic acid amide (28.4 g, 0.2 mol) and potassium ethylxanthate (96 g, 3 eq) were mixed together and added to DMF (1000 mL). The resulting mixture was heated to 150° C. for about six hours. The solvent (DMF) was removed on the rotovap under high vacuum at 90° C. The residue was diluted with 600 mL of aqueous citric acid (5%) and cooled to 0° C. and stirred for about 30 minutes. The tan powder was filtered and dried overnight to give 25.6 g of the title compound ((M+H)+=185, M.P.>300° C.).

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