Реакция #985327

Уравнение реакции

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide

sodium trimethylsilanolate

→

title compound

6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid

Растворители

DCE

Условия реакции

Обработка

1. 1
   Концентрированиеthe mixture was concentrated in vacuo
2. 2
   Другоеpurified by prep

Методика

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspended in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound.

Источник